!
! Episodic Ataxia/Myokymia pedigrees from Litt et al AJHG 1994; 55: 702-9
! used as an example for APM mapping by Davis et al. AJHG 1996; 58: 867-80
! 10 C12 markers
!
! pY21/1 == D12S1088
!
! pter--S91 S100 CACNL1A1 S372 pY2/1 pY21/1 KCNA5 S93 S99--cen
!          1.0  1.0     3.0 ------ 3.0 ------ 1.0   1.0
!
! multipoint LOD score analysis gives Zmax=11.35 between D12S99 and KCNA5
!
set impute on
set datadir ../pedigrees
set locus ep_ataxia aff
set locus D12S91 marker   1.03   817436
set locus D12S100 marker  4.76  2046844
set locus CACNL1A1 marker 5.00  2556212
set locus D12S372 marker  6.42  3457623
set locus pY2/1 marker   14.6 
set locus pY21/1 marker  14.7   4801018
set locus KCNA5 marker   14.8   5024750
set locus D12S93 marker  15.0   5201115
set locus D12S99 marker  15.2   5434861
read pedigree inline
4 2002 x    x    m n 1 1 1 4 9  10 2 2 1 5 5 7  3 4 4 7 4 6 
4 2001 x    x    f n x x x x x  x  x x x x x x  x x x x x x 
4 1001 x    x    m n 1 3 3 3 9  9  4 5 6 6 3 4  3 4 6 6 1 5 
4 1000 2002 2001 f y 1 3 4 6 10 10 2 3 1 2 7 7  2 3 4 7 3 6 
4 1002 2002 2001 m n 1 2 4 5 10 10 2 2 1 1 7 10 3 4 4 7 5 6 
4 1006 2002 2001 f y 1 3 4 6 10 10 2 3 1 2 7 7  2 3 4 7 3 6 
4 1007 x    x    m n 3 3 4 6 1  8  2 3 x x 4 7  2 4 3 4 3 6 
4 1008 2002 2001 f y 1 3 1 6 9  10 2 3 2 5 5 7  2 4 4 4 3 4 
4 1009 x    x    m n 1 2 3 3 2  9  2 3 1 1 4 5  1 2 1 1 2 5 
4 1010 2002 2001 f y 1 3 1 6 9  10 2 3 2 5 5 7  2 4 4 4 3 4 
4 1011 x    x    m n x x x x x  x  x x x x x x  x x x x x x 
4 100  1001 1000 m n 1 1 3 4 9  10 2 5 1 6 4 7  3 3 6 7 1 6 
4 102  1001 1000 m y 3 3 3 6 9  10 3 4 2 6 4 7  2 4 4 6 3 5 
4 103  x    x    f n 1 2 2 3 10 10 3 4 6 6 3 4  1 3 x x 4 6 
4 1    1001 1000 m y 1 3 3 6 9  10 3 5 2 6 3 7  2 3 4 6 1 3 
4 104  x    x    f n 1 4 3 4 9  9  2 3 6 6 5 10 1 1 3 6 7 8 
4 114  1007 1006 f y 3 3 6 6 8  10 3 3 2 6 4 7  2 2 4 4 3 3 
4 113  1007 1006 f y 3 3 4 6 1  10 2 3 1 6 4 7  2 3 4 7 3 6 
4 115  1009 1008 m y 1 3 3 6 9  10 2 3 1 2 4 7  2 2 1 4 3 5 
4 116  1011 1010 m y 3 3 2 6 9  10 3 3 1 2 4 7  1 2 4 4 3 4 
4 117  x    x    f n 1 3 1 4 8  9  2 3 5 6 5 5  4 4 4 4 4 4 
4 9003 102  103  m y 2 3 2 6 10 10 3 4 2 6 4 7  2 3 4 6 3 4 
4 9004 102  103  m n 1 3 3 6 10 10 3 3 6 6 3 4  1 4 4 6 5 6 
4 9005 1    104  f y 1 3 4 6 9  10 3 3 2 6 5 7  1 2 x x 3 7 
4 9006 1    104  m x 1 1 3 4 9  9  3 5 6 6 3 5  1 3 x x x x 
3 101  x    x    m y x x x x x  x  x x x x x x  x x x x x x 
3 102  x    x    f n x x x x x  x  x x x x x x  x x x x x x 
3 2082 x    x    f n x x x x x  x  x x x x x x  x x x x x x 
3 208  101  102  m y x x x x x  x  x x x x x x  x x x x x x 
3 205  101  102  f y x x x x x  x  x x x x x x  x x x x x x 
3 2051 x    x    m n x x x x x  x  x x x x x x  x x x x x x 
3 3332 x    x    f n x x 2 5 9  10 1 2 3 6 2 3  4 6 1 3 1 6 
3 333  208  2082 m y x x x x x  x  x x x x x x  x x x x x x 
3 341  208  2082 m n x x 3 3 9  9  3 3 3 6 3 4  3 6 2 3 6 7 
3 339  208  2082 f n x x 2 3 9  9  2 3 2 6 4 6  3 6 2 3 6 7 
3 336  208  2082 f n x x 2 3 9  9  2 3 2 3 4 6  3 3 3 3 7 8 
3 331  208  2082 f y x x 3 3 9  9  2 3 3 3 3 4  3 3 1 3 7 8 
3 332  208  2082 f y x x x x x  x  x x x x x x  x x x x x x 
3 3321 x    x    m n x x x x x  x  x x x x x x  x x x x x x 
3 334  208  2082 f y x x 3 3 9  9  3 3 3 6 x x  3 6 1 2 6 7 
3 3341 x    x    m n x x x x x  x  x x x x x x  x x x x x x 
3 335  208  2082 m y x x 3 3 9  9  3 3 3 6 3 4  3 6 1 2 6 7 
3 3352 x    x    f n x x 2 2 9  10 4 5 3 4 3 4  4 6 1 2 3 4 
3 322  2051 205  m n x x 3 5 8  9  4 4 2 2 3 6  3 6 2 3 2 7 
3 323  2051 205  f n x x 3 5 8  9  4 4 2 2 3 6  3 4 2 3 2 7 
3 325  2051 205  f y x x 2 3 9  9  3 4 3 3 3 3  3 4 1 2 6 7 
3 326  2051 205  f y x x 3 5 9  9  3 4 2 3 3 3  3 6 1 2 2 7 
3 324  2051 205  m y x x x x x  x  x x x x x x  x x x x x x 
3 3242 x    x    f n x x x x x  x  x x x x x x  x x x x x x 
3 4171 x    x    m n x x 3 5 9  9  2 4 1 4 3 3  4 4 1 2 1 6 
3 417  333  3332 f y x x 2 3 9  9  2 3 3 6 2 3  3 6 1 3 6 7 
3 418  333  3332 m n x x 2 3 9  9  2 3 6 6 2 4  6 6 2 3 6 6 
3 416  333  3332 m n x x 2 3 9  9  2 3 6 6 2 4  6 6 2 3 6 6 
3 415  333  3332 f y x x 3 5 9  10 1 3 3 3 3 3  x x 1 1 1 7 
3 4151 x    x    m n x x 2 2 9  9  4 4 2 3 3 6  x x 1 2 6 8 
3 414  3321 332  f y x x 2 3 7  9  4 4 3 7 2 3  x x 1 2 4 7 
3 411  3321 332  f n x x 2 3 9  9  3 4 3 6 4 4  4 6 1 2 6 8 
3 412  3321 332  f y x x 2 3 9  9  3 4 3 7 2 3  x x 1 2 4 7 
3 4121 x    x    m n x x 2 2 9  10 3 4 2 7 2 4  x x 2 2 3 5 
3 420  3341 334  m n x x 1 3 9  12 3 3 5 6 4 4  4 6 2 5 6 7 
3 419  3341 334  f n x x 1 3 9  12 3 3 5 6 4 4  4 6 2 5 6 7 
3 4211 x    x    m n x x 1 2 8  9  4 5 2 7 2 4  x x 2 3 6 8 
3 421  335  3352 f y x x 2 3 9  9  3 5 3 4 3 3  3 6 1 1 4 7 
3 423  335  3352 m n x x 2 3 9  9  3 5 4 6 3 4  6 6 1 2 4 6 
3 422  335  3352 f y x x 2 3 9  9  3 5 3 4 3 3  3 6 1 1 4 7 
3 4221 x    x    m n x x 3 3 8  12 1 4 3 3 2 3  6 6 1 3 6 7 
3 410  324  3242 f n x x 2 2 9  9  1 4 3 6 1 3  3 4 2 2 5 6 
3 409  324  3242 m y x x 2 3 9  9  1 3 3 6 1 3  3 3 1 2 5 7 
3 4092 x    x    f n x x 2 4 9  9  2 4 3 4 4 10 3 6 2 4 3 5 
3 512  4171 417  f n x x 2 5 9  9  2 2 4 6 2 3  4 6 2 3 6 6 
3 511  4151 415  f y x x 2 3 9  9  3 4 2 3 3 6  3 4 1 2 7 8 
3 510  4151 415  f n x x 2 5 9  10 1 4 2 3 3 6  4 4 1 2 1 8 
3 504  4121 412  m n x x 2 2 9  9  3 4 7 7 2 2  6 6 2 2 4 5 
3 503  4121 412  f y x x 2 3 9  10 3 4 2 3 3 4  3 4 2 1 3 7 
3 513  4211 421  m y x x 2 3 8  9  3 4 2 3 3 4  3 4 1 3 6 7 
3 514  4211 421  f n x x 1 2 9  9  5 5 4 7 2 3  6 6 1 2 4 8 
3 516  4221 422  f n x x 2 3 8  9  4 5 3 4 2 3  6 6 1 1 4 7 
3 515  4221 422  m y x x 2 3 9  12 1 5 3 3 3 3  3 6 1 3 6 7 
3 501  409  4092 f y x x 2 2 9  9  1 4 3 3 3 10 3 3 1 4 3 7 
;;;;
run
apm ep_ataxia ibd
tdt ep_ataxia
assoc ep_ataxia
sibpair ep_ataxia 
