#
# Seven Acadian pedigrees segregating Ushers syndrome 1c
# From Figure 1 of Ayyagari R, Li Y, Smith RJH et al (1995)
# Fine Mapping of the Usher Syndrome Type IC to Chromosome 11p14 and
# Identification of Flanking Markers by Haplotype Analysis
# Mol. Vis. 1:2.
#
set locus ushers   aff .                     
set locus D11S861  mar 28.081 chr11:14448976 
set locus D11S419  mar 29.936 chr11:15913066 
set locus D11S1397 mar 30.279 chr11:16154142 
set locus D11S1890 mar 31.560 chr11:16960872 
set locus D11S921  mar 32.067 chr11:17241008 
set locus D11S902  mar 32.449 chr11:17445082 
#         harmonin            chr11:17522539-17472018
set locus D11S1888 mar 33.009 chr11:17734511 
set locus D11S1310 mar 33.331 chr11:17896608 
read pedigree inline
101 1  x x m n 2/3 2/2 1/3 1/2 3/3 3/4 1/4 3/4 
101 2  x x f n 1/3 2/2 1/3 2/4 2/3 2/4 2/4 4/4 
101 3  1 2 f n 1/2 2/2 3/3 1/4 2/3 2/3 1/2 3/4 
101 4  1 2 f n 1/3 2/2 1/3 2/4 2/3 2/4 2/4 4/4 
101 5  1 2 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
101 6  1 2 f y x/x x/x x/x x/x x/x x/x x/x x/x 
102 4  x x m n 3/4 2/2 1/1 2/2 3/3 2/4 2/4 3/4 
102 5  x x f n 2/3 1/2 1/1 2/5 1/3 2/4 1/4 4/4 
102 7  4 5 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
102 8  4 5 f n 2/3 1/2 1/1 2/5 1/3 2/4 1/4 4/4 
102 9  4 5 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
102 10 4 5 m n 2/4 1/2 1/1 2/5 1/3 2/2 1/2 3/4 
102 11 4 5 m y 3/4 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
102 12 4 5 m n 2/3 1/2 1/1 2/5 1/3 2/4 1/4 4/4 
103 1  x x m n 1/3 2/2 1/1 2/3 1/3 2/4 1/4 2/4 
103 2  x x f n 1/3 1/2 1/1 2/3 3/3 1/4 3/4 3/4 
103 3  1 2 m n x/x x/x x/x x/x x/x x/x x/x x/x 
103 4  1 2 m y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
103 5  1 2 m n 1/3 1/2 1/1 2/3 3/3 1/4 3/4 3/4 
104 1  x x m n 3/5 2/2 1/1 1/2 3/3 3/4 3/4 4/4 
104 2  x x f n 1/3 1/2 3/3 2/2 3/3 2/4 2/4 1/4 
104 3  1 2 m y 3/3 2/2 1/3 2/2 3/3 4/4 4/4 4/4 
104 5  1 2 m n 3/5 2/2 1/3 1/2 3/3 3/4 3/4 4/4 
104 6  1 2 m y 3/3 2/2 1/3 2/2 3/3 4/4 4/4 4/4 
104 7  1 2 m n 3/5 2/2 1/3 1/2 3/3 3/4 3/4 4/4 
104 8  1 2 m n 3/5 2/2 1/3 1/2 3/3 3/4 3/4 1/4 
105 1  x x f n 3/4 1/2 1/1 2/2 1/3 3/4 1/4 2/4 
105 6  x x m n 1/3 1/2 1/1 2/2 2/3 2/4 1/4 1/2 
105 2  6 1 m n 1/4 1/1 1/1 2/2 1/2 2/3 1/1 1/2 
105 3  6 1 f n 1/3 1/2 1/1 2/2 2/3 2/4 1/4 1/4 
105 4  6 1 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 2/4 
105 9  6 1 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 2/4 
105 10 6 1 m y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 2/4 
106 1  x x m n 2/3 2/2 1/3 2/2 1/3 3/4 1/4 3/4 
106 2  x x f n 3/6 1/2 1/2 2/2 3/3 2/4 2/4 2/4 
106 3  1 2 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
106 4  1 2 f n 2/3 2/2 1/3 2/2 1/3 3/4 1/4 3/4 
106 5  1 2 m y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
106 6  1 2 m n 3/6 1/2 1/2 2/2 3/3 2/4 2/4 2/4 
107 2  x x f n x/x x/x x/x x/x x/x x/x x/x x/x 
107 6  x x m n 1/3 1/2 1/1 2/2 3/3 2/4 2/4 4/5 
107 1  6 2 m y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
107 3  6 2 f n 1/3 1/2 1/1 2/2 3/3 2/4 2/4 4/5 
107 5  6 2 f y 3/3 2/2 1/1 2/2 3/3 4/4 4/4 4/4 
;;;;
run
set ple -2
set loc proband aff
edit 101 5 proband to y
edit 102 7 proband to y
edit 103 4 proband to y
edit 104 3 proband to y
edit 105 4 proband to y
edit 106 3 proband to y
edit 107 1 proband to y
set ple 0
