!
! Genetic linkage evidence for a familial Alzheimer's disease locus on
! Chromosome 14.  Schellenberg GD, Bird TD, Wijsman E, Harry T, Anderson L,
! Nemens E et al.  Science 1992; 258: 668-671
!
! Three Volga German families taken from Figure 1 out of 14 described.
! Note these are altered to protect confidentiality and sexes were not shown.
! Genotypes at three markers are given, along with Z at r=0 (Zmax):
!
!                   .207          .025
! Family    D14S52 ------ D14S43 ------ D14S53
! AM       -2.70 (.08)    0.00 (.02)    1.49
! L         1.82          4.89         -4.57 (2.44 at r=0.05)
! SNW       0.87          2.17          0.66
!       
! Genehunter at D14S43 gave:
!      NPL    p-value
!  AM  0.3504 0.23047
!   L  0.6947 0.10021
! SNW  0.4554 0.02948
!
set mincount 50
set iter 5000
set data ../pedigrees
set locus AD aff
set locus onset qua
set locus age qua
set locus D14S52 mar
set locus D14S43 mar
set locus D14S53 mar
set locus proband aff
rea ped inline
 AM 101   x   x m y 43  x   x   x   x   x   x   x n
 AM 102   x   x f n 77 77  83  87 183 183 151 151 n
 AM 201 101 102 m y 41  x   x   x   x   x   x   x y
 AM 202 101 102 m y 43  x   x   x   x   x   x   x n
 AM 203   x   x f n  x  x  83  93 171 181 151 157 n
 AM 204 101 102 m n 63 63   x   x   x   x   x   x n
 AM 205 101 102 m y 46  x  83  87 183 183 151 155 n
 AM 206 101 102 m y 41  x  83  87 183 183 151 155 n
 AM 207 101 102 m n 52 52   x   x   x   x   x   x n
 AM 208 101 102 m y 41  x  83  87 183 183 151 155 n
 AM 209 101 102 m y 45  x  87  87 183 183   x   x n
 AM 210 101 102 m n 49 49   x   x   x   x   x   x n
 AM 301 202 203 m y 36  x  57  93 181 183 151 155 n
  L 101   x   x m y 41  x   x   x   x   x   x   x n
  L 102   x   x f n  x  x   x   x   x   x   x   x n
  L 201 101 102 m y 48  x   x   x   x   x   x   x n
  L 202   x   x f n 77 77   x   x   x   x   x   x n
  L 203 101 102 m y 36  x   x   x   x   x   x   x n
  L 204 101 102 m y 48  x   x   x   x   x   x   x n
  L 205   x   x f n  x  x   x   x   x   x   x   x n
  L 206 101 102 m n 84 84  83  83 185 187 151 151 n
  L 207 101 102 m n 78 78  83  83 179 185 149 151 n
  L 301   x   x m n  x  x   x   x   x   x   x   x n
  L 302 201 202 f y 43  x   x   x   x   x   x   x y
  L 303 201 202 m n 63 63   x   x   x   x   x   x n
  L 304 201 202 m y 30  x   x   x   x   x   x   x n
  L 305   x   x f n  x  x   x   x   x   x   x   x n
  L 306 201 202 m y 45  x   x   x   x   x   x   x n
  L 307 201 202 m n 58 58   x   x   x   x   x   x n
  L 308 201 202 m y 41  x   x   x   x   x   x   x n
  L 309 201 202 m n 56 56  81  85 181 187 151 151 n
  L 310 201 202 m y 39  x   x   x   x   x   x   x n
  L 311 201 202 m n 53 53   x   x   x   x   x   x n
  L 312 201 202 m n 49 49   x   x   x   x   x   x n
  L 313 201 202 m n 41 41   x   x   x   x   x   x n
  L 314 201 202 m y 44  x  85  87 159 181 151 151 n
  L 315 201 202 m y 39  x  81  85 159 181 144 151 n
  L 316 204 205 m y 39  x  85  87 159 159 144 151 n
  L 317 204 205 m y 40  x  83  85 159 159 144 151 n
  L 318 204 205 m y 41  x  83  85 159 159 144 151 n
  L 319 204 205 m n 41 41   x   x   x   x   x   x n
  L 401 301 302 m y 45  x  83  85 159 183 144 151 n
  L 402 304 305 m y 47  x  83  85 159 159 144 144 n
SNW 101   x   x m y  x  x   x   x   x   x   x   x n
SNW 102   x   x f n  x  x   x   x   x   x   x   x n
SNW 201 101 102 m y 61 61   x   x   x   x   x   x n
SNW 202   x   x f n  x  x   x   x   x   x   x   x n
SNW 203 101 102 m y 61 61   x   x   x   x   x   x n
SNW 204   x   x f n  x  x   x   x   x   x   x   x n
SNW 205 101 102 m y 57 57   x   x   x   x   x   x n
SNW 206   x   x f n  x  x   x   x   x   x   x   x n
SNW 207 101 102 m y 59 59   x   x   x   x   x   x n
SNW 208   x   x f n  x  x   x   x   x   x   x   x n
SNW 209 101 102 m n 50 50   x   x   x   x   x   x n
SNW 210   x   x f n  x  x   x   x   x   x   x   x n
SNW 301   x   x m n  x  x   x   x   x   x   x   x n
SNW 302 201 202 f y 66 66   x   x   x   x   x   x n
SNW 303 203 204 m y 64 64   x   x   x   x   x   x n
SNW 304   x   x f n  x  x   x   x   x   x   x   x n
SNW 305 203 204 m y 60 60   x   x   x   x   x   x n
SNW 306 203 204 m y 52  x   x   x   x   x   x   x n
SNW 307 205 206 m n 80 80   x   x   x   x   x   x n
SNW 308 205 206 m y 54  x   x   x   x   x   x   x n
SNW 309 207 208 m y 44  x   x   x   x   x   x   x y
SNW 310   x   x m n  x  x   x   x   x   x   x   x n
SNW 311 207 208 f y 53 53   x   x   x   x   x   x n
SNW 312 207 208 m y 51 51   x   x   x   x   x   x n
SNW 313 207 208 m y 53  x   x   x   x   x   x   x n
SNW 314 207 208 m n 67 67   x   x   x   x   x   x n
SNW 315 209 210 m y 56  x  83  87 159 187 148 151 n
SNW 401 301 302 m n 73 73   x   x   x   x   x   x n
SNW 402 301 302 m y 50  x  83  83 185 187 151 151 n
SNW 403 301 302 m n 76 76   x   x   x   x   x   x n
SNW 404 301 302 m y 56 56   x   x   x   x   x   x n
SNW 405 301 302 m n 72 72   x   x   x   x   x   x n
SNW 406 303 304 m y  x  x  69  83 185 187 151 151 n
SNW 407 310 311 m y 50  x  83  87 181 187 144 151 n
;;;;
run
